Rising to the Challenge: The Strategies of Social Service Intermediaries

During the past decade, "intermediary organizations" have proliferated across the nonprofit sector. These organizations are typically positioned between funding entities (e.g., government agencies, foundations and corporations) and direct service providers. Intermediaries play an important roll in connecting organizations that share a common interest--and working to enhance the services these organizations provide, build larger service networks, promote quality standards, and monitor programs on behalf of funders

Smashing Birds in the Wilderness: British Racial and Cultural Integration from Insider and Outsider Perspectives

A review on a group of young adult novels thematising British multiculturalism as it plays out in relations between young characters of different ethnic origins is presented. The analysis of these texts suggests that in many cases racial and cultural difference is named through descriptions of characters, but not pursued through thematics or language, and thus issues of community relations and individual identities are represented through shallow and celebratory treatments, which contradict the complexities of British multiculturalism

British Activist Authors Addressing Children of Colour

Exploring a history of activists writing for and about children of colour from abolition to Black Lives Matter, this open access book examines issues such as the space given to people of colour by white activists; the voice, agency and intersectionality in activist writing for young people; how writers used activism to expand definitions of Britishness for child readers; and how activism and writing about it has changed in the 21st century. From abolitionists and anti-colonialists such as Amelia Opie, Una Marson and Rabindranath Tagore; communist and feminist activists concerned with broader children’s rights including Chris Searle and Rosemary Stones; to Black Panthers and contemporary advocates for people of colour from Farrukh Dhondy to Len Garrison, Catherine Johnson and Corinne Fowler, Karen Sands-O'Connor traces how these activists translated their values for children of colour. Beginning with historical events that sparked activism and the first cultural products for children and continuing to contemporary activism in the wake of the Windrush Scandal, this book analyses the choices, struggles and successes of writers of activist literature as they tried to change Britain and British literature to make it a welcoming place for all child readers. The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollection.com. Open access was funded by Knowledge Unlatched

Audio and video processing for automatic TV advertisement detection

As a partner in the Centre for Digital Video Processing, the Visual Media Processing Group at Dublin City University conducts research and development in the area of digital video management. The current stage of development is demonstrated on our Web-based digital video system called Físchlár [1,2], which provides for efficient recording, analyzing, browsing and viewing of digitally captured television programmes. In order to make the browsing of programme material more efficient, users have requested the option of automatically deleting advertisement breaks. Our initial work on this task focused on locating ad-breaks by detecting patterns of silent black frames which separate individual advertisements and/or complete ad-breaks in most commercial TV stations. However, not all TV stations use silent, black frames to flag ad-breaks. We therefore decided to attempt to detect advertisements using the rate of shot cuts in the digitised TV signal. This paper describes the implementation and performance of both methods of ad-break detection

Simulation of the Elastic Properties of Reinforced Kevlar-Graphene Composites

The compressive strength of unidirectional fiber composites in the form of Kevlar yarn with a thin outer layer of graphene was investigated and modeled. Such fiber structure may be fabricated by using a strong chemical bond between Kevlar yarn and graphene sheets. Chemical functionalization of graphene and Kevlar may achieved by modification of appropriate surface-bound functional (e.g., carboxylic acid) groups on their surfaces. In this report we studied elastic response to unidirectional in-plane applied load with load peaks along the diameter. The 2D linear elasticity model predicts that significant strengthening occurs when graphene outer layer radius is about 4 % of kevlar yarn radius. The polymer chains of Kevlar are linked into locally planar structure by hydrogen bonds across the chains, with transversal strength considerably weaker than longitudinal one. This suggests that introducing outer enveloping layer of graphene, linked to polymer chains by strong chemical bonds may significantly strengthen Kevlar fiber with respect to transversal deformations

Nfix expression critically modulates early B lymphopoiesis and myelopoiesis

The commitment of stem and progenitor cells toward specific hematopoietic lineages is tightly controlled by a number of transcription factors that regulate differentiation programs via the expression of lineage restricting genes. Nuclear factor one (NFI) transcription factors are important in regulating hematopoiesis and here we report an important physiological role of NFIX in B- and myeloid lineage commitment and differentiation. We demonstrate that NFIX acts as a regulator of lineage specification in the haematopoietic system and the expression of Nfix was transcriptionally downregulated as B cells commit and differentiate, whilst maintained in myeloid progenitor cells. Ectopic Nfix expression in vivo blocked early B cell development stage, coincident with the stage of its downregulation. Furthermore, loss of Nfix resulted in the perturbation of myeloid and lymphoid cell differentiation, and a skewing of gene expression involved in lineage fate determination. Nfix was able to promote myeloid differentiation of total bone marrow cells under B cell specific culture conditions but not when expressed in the hematopoietic stem cell (HSPC), consistent with its role in HSPC survival. The lineage choice determined by Nfix correlated with transcriptional changes in a number of genes, such as E2A, C/EBP, and Id genes. These data highlight a novel and critical role for NFIX transcription factor in hematopoiesis and in lineage specification

Efficacy of nisin A and nisin V semi-purified preparations alone and in combination with plant essential oils to control Listeria monocytogenes

peer-reviewedThe foodborne pathogenic bacterium Listeria is known for relatively low morbidity and high mortality rates reaching up to 25-30%. Listeria is a hardy organism and its control in foods represents a significant challenge. Many naturally occurring compounds, including the bacteriocin nisin and a number of plant essential oils, have been widely studied and are reported to be effective as antimicrobial agents against spoilage and pathogenic microorganisms. The aim of this study was to investigate the ability of semi-purified preparations (spp) containing either nisin A or an enhanced bioengineered derivative nisin V, alone and in combination with low concentrations of the essential oils thymol, carvacrol and trans-cinnamaldehyde, to control L. monocytogenes in both laboratory media and model food systems. Combinations of nisin V-containing spp (25 μg/ml) with thymol (0.02%), carvacrol (0.02%) or cinnamaldehyde (0.02%) produced a significantly longer lag phase than any of the essential oil/nisin A combinations. In addition, the log reduction in cell counts achieved by the nisin V + carvacrol or nisin V + cinnamaldehyde combinations was twice that of the equivalent nisin A + essential oil treatment. Significantly, this enhanced activity was validated in model food systems against L. monocytogenes strains of food origin. We conclude that the fermentate form of nisin V in combination with carvacrol and cinnamaldehyde offers significant advantages as a novel, natural and effective means to enhance food safety by inhibiting foodborne pathogens such as L. monocytogenes.This work was supported by the Irish Government under the National Development Plan, through Science Foundation Ireland Investigator awards to C.H. and R.P.R. (10/IN.1/B3027), and C.H., R.P.R. and P.D.C. (06/IN.1/B98)